AHMED KHAN ZARDARI . ALI AKBAR SIDDIQUI . NASURULLAH AMIR

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Background: Worldwide, OPC are the most widely used insecticides in developing countries like Pakistan, where agriculture is the main occupation and easily available every where, therefore, the OPC poisoning is very common. WHO recently reports that pesticides poisoning occurs about 3 million/ year with mortality > 3 lac/ year & 99% belong to developing countries.

Objective: To observe the neurological manifestations in OPC poisoning.

Methodology: Prospective observational study, conducted from Dec 2008 to April 2010 in Department of anaesthesia and Intensive Care Unit (ICU) at Liaquat University of Medical & Health Sciences, Jamshoro / Hyderabad.

Results: Out of 70 adult patients, 28(40%) were male and 42(60%) were female. Forty one (58.6%) were Suicidal, 10(14.3%) were Field workers /Farmers, 08(11.4%) were House workers, 06(8.6%) were College Students and 05(7.1%) were Accidental/Incidental cases. There was a high ratio of insecticides (Melathion, Parathion, and Mite/rat House fly killer Carbamates) by Ingestion / Inhalation route. The Cardiac manifestations were as; Sinus Tachycardia in 20(28.6%), Non Cardiac Pulmonary Edema and Sinus Bradycardia was found in 15(21.4%) in each, while Hypertension was found in 13(18.6%) and Hypotension was observed in 07(10%).Common ECG Changes noted in our study were; Prolonged QTc