ALTAF AHMED TALPUR . NAND LAL KELLA . ABDUL RASHID SURAHIO . MUHAMMAD JAVED . PROFESSOR AKMAL JAMAL
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Background: Enteric fever caused by Salmonella Typhi, gram negative bacilli, is counted as a major public health problem, especially in underdeveloped countries of tropic region. One of the notorious and potentially lethal complications of typhoid fever is small bowel perforation. Chloramphenicol, in 1948 converted this lethal disease to curable one. Efficacy of this drug reduced within 2 years. These strains of salmonella typhi were also found resistant to sulphonamide, tetracycline and streptomycin and are called as multidrugresistant strains salmonella typhi (MDRST). Due to this resistance amoxycilin, and trimethprim with sulphamethoxazole replaced these drugs. Emergence of MDRST led to the use of quinolones as the first line drug. With the developing resistance to flouroquinolones, 3rd generation cephalosporins such as ceftriaxone and cefotaxime are now increasingly being used in the treatment of typhoid fever.
Materials and Methods: This prospective, descriptive study was conducted at surgical ward- III of Liaquat university hospital, Hyderabad from Jan 2007 to Dec 2010. All patients of either sex above the age of 02 years having high-grade fever for more than 1 week associated with features of peritonitis secondary to hollow viscus perforation and later on confirmed through various investigations as cases of perforation of hollow viscus due to typhoid were included in the study. Subject